SIGNATURE
Advanced Wellness Patch
Signature is the all-round wellness patch and the essence of the Mepho collection. Designed for people who experience tension, fatigue, imbalance, or reduced vitality in everyday life.
21 patches
€ 39,75
- Free shipping: NL €50+ · EU €70+ · UK £70+
- Delivery: 1–4 business days
Non-invasive · Additive-free · SGS-tested
When Signature Makes Sense
Signature is chosen when support is needed as part of everyday life, not just in response to a single moment. It is designed for people who experience tension, fatigue, imbalance, or reduced vitality on a regular basis and are looking for steady, repeatable support rather than quick fixes.
Signature is based on the Acu-Resonance Method™, which works with your body’s natural warmth and acupoint-inspired placement associated with balance and vitality. It does not rely on additives, active ingredients, or invasive methods, and fits easily into everyday routines.
The experience is subtle and personal. Some people notice gentle changes early on, while for others the effect builds gradually with consistent use. It is also normal to feel very little while wearing the patch. Signature is designed to work quietly in the background, without forcing sensation.
Designed for regular use during the day or overnight, Signature can also be applied locally to help ease areas of tension or pain when needed.
Non-invasive · Additive-free · SGS-tested · Suitable for daily use
A different approach to wearable support
Signature uses the Acu-Resonance Method™, Mepho’s approach to wearable support. Each patch contains a specially developed layer that is activated by the body’s natural warmth. When placed on specific acupoint-inspired locations, it provides subtle, non-invasive support.
Instead of relying on active ingredients or external stimulation, the method works passively with the body’s own warmth. The interaction is gentle and continuous, designed to support the body without overriding its natural processes.
Inspired by principles from traditional acupuncture, the Acu-Resonance Method™ translates point-based support into a wearable patch format. It’s non-invasive and additive-free
The method is intentionally designed for both regular and situational use. By avoiding additives and overstimulation, it fits naturally into everyday life as a consistent and non-invasive form of support.
Each product in the Mepho collection applies this method in its own way. Signature uses it to provide all-round support for broad, everyday use.
Signature applies the Acu-Resonance Method™ through a three-point system designed for balanced, everyday support.
Once applied to the skin, the patches are activated by the body’s natural warmth. The special layer inside each patch responds to this warmth and interacts locally with the skin. The acupoint stimulation continues while you wear the patch, supporting balance and vitality without active ingredients or invasive techniques.
Signature is applied to three acupoint-inspired locations drawn from ancient acupuncture principles. These points are traditionally associated with different aspects of balance and vitality and are selected to work together as a system:
GV14 (Da Zhui)
Located at the base of the neck, this acupoint is traditionally associated with overall balance and the regulation of energy flow.
ST36 (Zu San Li)
Located below the knee, this acupoint is commonly linked to vitality, resilience, and sustained energy.
CV6 (Qi Hai)
Located on the lower abdomen, this acupoint is traditionally connected to core energy and physical stability.
Rather than focusing on a single point or function, Signature applies combined stimulation across these three acupoints. This coordinated approach supports balance and vitality, while helping the body manage stress and fatigue more effectively.
The interaction is subtle and does not rely on noticeable sensation. Some people feel very little while wearing the patch. This is normal. Signature is designed to work quietly in the background, allowing the body’s own processes to remain in the lead.
For exact placement and step-by-step guidance, see How to Apply.
Applying Signature is simple. Follow the steps below and use the diagram for visual guidance.
Step 1 | Prepare the skin
Clean and dry the skin before application.
Step 2 | Apply to the three acupoints
Apply one patch to each acupoint shown in the diagram.
GV14 | Da Zhui
Location: Base of the neck
How to find it: Tilt your head slightly forward and feel for the bony bump at the base of the neck. Apply the patch just below this point, centered along the spine.
ST36 | Zu San Li
Location: Below the knee
How to find it: Sit down and place four fingers below the kneecap. Move slightly to the outside of the shinbone. At the level of your little finger, you’ll feel a small dip. This is ST36.
CV6 | Qi Hai
Location: Lower abdomen
How to find it: Place two finger widths below the navel, on the midline of the body. Apply the patch directly beneath this point.
Step 3 | Secure and wear
Press each patch gently to ensure good adhesion. Wear for up to 8–12 hours, during the day or overnight, as needed.
Step 4 | Remove
Remove and discard after single use.
Alternative use (pain relief)
For local discomfort, apply the patch directly to the area of tension or pain.
Notes
- For external use only.
- Discontinue use if skin irritation occurs.
- SGS-tested for non-irritation.
- Signature is not a medication and does not replace professional medical care.
Yes. Signature is designed for regular, everyday use. It is non-invasive, additive-free, and SGS-tested. Many people incorporate it into their daily or near-daily routine.
Signature patches are typically worn for 8–12 hours. They can be worn during the day or overnight, depending on what fits best into your routine.
Yes. Signature is designed as a three-point system. Using all three patches together supports the method as intended and provides balanced, all-round support.
The experience is often subtle. Some people notice gentle changes over time, while others feel very little while wearing the patches. Both experiences are normal. Signature does not rely on noticeable sensation.
Yes. Signature can be worn while sleeping and normal daily activities, including exercise, as long as the patches remain comfortable and securely in place.
Signature is SGS-tested and free from active ingredients. If you have sensitive skin, start with a shorter wear time and check your skin after use. Discontinue use if irritation occurs.
Yes. In addition to its all-round use, Signature can be applied directly to an area of tension or discomfort when local support is needed.
Signature can be used daily, every other day, or several times a week. Regular use over time is more important than occasional or one-off use.
Experiences vary. Some people notice subtle changes early on, while for others the effect builds gradually with consistent use. There is no fixed timeline.
Not feeling anything is normal and does not mean the patch isn’t working. Signature is designed to work quietly in the background rather than create strong sensations.
No. Signature patches are designed for single use only and should be discarded after wearing.
No. The patches should be removed before showering or swimming, as water can affect adhesion.
Placement does not need to be exact to the millimeter. Applying the patches as shown in the How to Apply section ensures correct positioning for intended use.
Store the patches in a cool, dry place, away from direct sunlight. Keep them sealed until use.
If you are pregnant, have a medical condition, or are under medical supervision, consult a healthcare professional before use.
No. Signature is not a medication and is not intended to replace professional medical care.
Product information
Signature is a non-invasive wellness patch. It is not a medical device or medication and is not intended to diagnose, treat, cure, or prevent any disease. Individual experiences may vary. If you have a medical condition, are pregnant, or are under medical supervision, consult a healthcare professional before use.
Hygiene & returns
Signature is a sealed hygienic product. For hygiene and safety reasons, the right of withdrawal expires once the seal has been broken or the packaging has been opened.




